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Istomin outplayed Dmitry Tursunov of Russia in four sets in the first round - 7:5, 6:3, 3:6 and 6:2.
The match lasted two hours and 23 minutes. Denis Istomin broke his opponent twice and lost two of his own serves.
Uzbek player recorded 16 aces and committed two double faults. Tursunov recorded 11 aces and six double faults during the match.
Denis Istomin will face Julian Reister of Germany in the second round of Wimbledon.