Four clubs will participate in the 2015 AFC Champions League from Uzbekistan - Pakhtakor (League champions), Locomotiv (Uzbek Cup winners and League runners-up), Nasaf (League third place) and Bunyodkor (League fourth place).

Bunyodkor will participate in qualification round against Al-Jazira. The match will be held in Tashkent on 17 February. The winner will play in Group A along with Nassr (Saudi Arabia), Lekhwiya (Qatar) and Persepolis (Iran).

Pakhtakor, Locomotiv and Nasaf will start their AFC Champions League campaign from the group stage on 24-25 February.

Pakhtakor will face Al Shabab (Saudi Arabia) and Al Ain (UAE). The third opponent will be determined after play-off match.

Locomotiv is in Group C along with Foolad Khuzestan (Iran) and Al Hilal (Saudi Arabia). The third opponent will be determined after play-off match.

Nasaf will play in Group D against Al Ahli (UAE), Tractorsazi Tabriz (Iran) and the winner of play-off match.