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Davron Hoshimov of Pakhtakor opened the score on 46 minutes, but Nasibullaev scored equalizer after 11 minutes.
Mansur Saidov (66) and Anvar Berdiev (82) netted goals to give all three points to Neftchi Ferghana.
This is the first loss of Pakhtakor in the league this season. It is worth to mention that Neftchi also handed the first defeat to Nasaf Karshi several days ago.